What is semaglutide and how to obtain a prescription for GLP-1 medications?

What is semaglutide and why is everyone talking about GLP-1 medications? Learn how these medications help with weight loss and how to obtain a prescription for semaglutide and other similar medications like tirzepatide.

What is semaglutide and how does it work for weight loss?

Semaglutide belongs to a class of medications known as GLP-1 agonists. It works by mimicking GLP-1, which is a digestive hormone in the GI tract. This increase in GLP-1 causes the stomach to empty more slowly, extending the feeling of fullness, and also works in the brain to reduce appetite. This results in prolonged satiety and decreased hunger cravings, which leads to weight loss.

How can someone get a prescription for semaglutide for weight loss?

Patients may ask their licensed family physician for a prescription for semaglutide, which is the generic medication for Ozempic (FDA-approved for type 2 diabetes) and Wegovy (FDA-approved for weight loss). However, there are often many barriers in terms of cost and access to these medications through a traditional family medicine clinic/retail pharmacy so many patients will opt for weight loss-specific clinics, in person or online, that often offer compounded semaglutide or other options to make semaglutide more affordable and accessible to the average patient.

What is the eligibility criteria for a prescription?

General eligibility criteria for semaglutide includes people with a BMI of 30 or greater, or 27 or greater with at least one weight-related health condition such as high blood pressure, type 2 diabetes, or high cholesterol.

Does insurance typically cover semaglutide?

Semaglutide is sometimes covered by insurance for patients with documented type 2 diabetes.

What are some of the alternatives to semaglutide?

Tirzepatide is a newer alternative to semaglutide. Tirzepatide, which is sold under the brand name Mounjaro for diabetes and Zepbound for weight loss, is similar to semaglutide, but is a GLP-1/GIP agonist. Tirzepatide is generally thought to be more effective than semaglutide for weight loss, although studies show both to be very effective weight loss medications.

There are older generic medications like phentermine or topiramate that are sometimes used for weight loss or other newer branded medications that are FDA-approved for weight loss. However, studies show that none of these medications are as effective as the GLP-1 class of medications.

What should you do if you are having trouble with weight loss?

People should visit their physician's office to rule out other medical conditions that can contribute to weight gain such as thyroid disease or sleep apnea.

Diet and exercise should always be included in any comprehensive weight loss program.

Medications, if indicated, can help with weight loss alongside a healthy diet and exercise program.

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